Approaching ryanodine receptor therapeutics from the calcin angle
نویسندگان
چکیده
منابع مشابه
Approaching ryanodine receptor therapeutics from the calcin angle
The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 147 No. 5 369–373 www.jgp.org/cgi/doi/10.1085/jgp.201611599 369 Release of Ca from intracellular stores is a ubiquitous mechanism that contributes to numerous physiological processes, including secretion, transcription, apoptosis, and contraction. In many cases, the rise in intracellular Ca is mediated by Ca release channels cal...
متن کاملApproaching ryanodine receptor therapeutics from the calcin angle
The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 147 No. 5 369–373 www.jgp.org/cgi/doi/10.1085/jgp.201611599 369 Release of Ca from intracellular stores is a ubiquitous mechanism that contributes to numerous physiological processes, including secretion, transcription, apoptosis, and contraction. In many cases, the rise in intracellular Ca is mediated by Ca release channels cal...
متن کاملApproaching ryanodine receptor therapeutics from the calcin angle
The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 147 No. 5 369–373 www.jgp.org/cgi/doi/10.1085/jgp.201611599 369 Release of Ca from intracellular stores is a ubiquitous mechanism that contributes to numerous physiological processes, including secretion, transcription, apoptosis, and contraction. In many cases, the rise in intracellular Ca is mediated by Ca release channels cal...
متن کاملStructure–function relationships of peptides forming the calcin family of ryanodine receptor ligands
Calcins are a novel family of scorpion peptides that bind with high affinity to ryanodine receptors (RyRs) and increase their activity by inducing subconductance states. Here, we provide a comprehensive analysis of the structure-function relationships of the eight calcins known to date, based on their primary sequence, three-dimensional modeling, and functional effects on skeletal RyRs (RyR1). ...
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In this work, targeting, e.g., future generation cellular, microwave-links, or optical fiber systems, we propose a new geometric shaping design for golden angle modulation (GAM) based on a (double) truncated Gaussian input distribution. The design improves the mutual information (MI), and the peak-toaverage power ratio, over the full signal-to-noise ratio (SNR) range relative to two key GAM sch...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2016
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.201611599